Association between Neutrophil-Lymphocyte Ratio and Incidence of Acute Kidney Injury (AKI) Related Drug in Post-Surgical ICU Patients at Haji Adam Malik Hospital Medan
Author(s): Daniel Amudi Gunawan Hutapea, Andriamuri Primaputra Lubis* and Tasrif Hamdi
Abstract
Background: Postoperative AKI is a common complication of surgery. The incidence of postoperative AKI varies according to the type of surgery and most studies are limited to cardiac surgery. Blood Neutrophil- lymphocyte Ratio (RNL) is one of the good systemic inflammatory markers to predict AKI. The Neutrophil-lymphocyte Ratio (RNL) has been studied as a predictor of postoperative AKI in various surgical contexts. A higher NLR was found to be associated with an increased risk of postoperative AKI after major abdominal surgery. Another study found that a high NLR was associated with an increased risk of developing AKI in patients undergoing cardiac surgery. These findings suggest that NLR may be a useful biomarker for predicting postoperative AKI, but further
studies are needed to establish its clinical utility and to determine the optimal cut-off for risk stratification.
Method: This study used a retrospective analytic method with the aim of knowing the relationship between the value of the neutrophil-lymphocyte ratio and the incidence of AKI in post-surgical ICU patients at H. Adam Malik Hospital Medan. The total sample in this study was 188 patients taken in the period January 2023-December 2023. The samples were then analyzed using the Independent T test to see the relationship between the 2 research groups.
Research result: The value of neutrophil lymphocyte ratio to the incidence of AKI, in Non AKI patients obtained neutrophil lymphocyte ratio 18.62 ± 7.91, in AKI patients obtained neutrophil lymphocyte ratio 47.57 ± 29,85, with a P Value of 0.01. The NLR cut off value was found to be 23.14 with a large AUC value of 86.3% with a sensitivity of 86% and a specificity of 62% where there was a relationship between the NLR value and the incidence of AKI.
Conclusion: There is a relationship between the value of neutrophil lymphocytes and the incidence of AKI.
