Comparative In-Vitro Antihelmintic Activity of Prepared, Branded and Generic Albendazole Samples in Pheretima Posthuma
Author(s): Kanaka Durga Devi Nelluri*, Aminabee Shaik, Baluguri Radha Madhavi, Anne lakshmi pavani, Tanneeru Anasurya, Sahithi Kamepalli, Vejandla Swathi Lakshmi, Vemuri Sravya, Sure Sai Krishna, Gandreti Maha Lakshmi Manasa, Alla Nagalakshmi and Kundurthi Surendra
Abstract
Albendazole is a benzimidazole derivative with great tolerability and broad-spectrum anthelmenthic action. Albendazole tablets (400 mg) were made using 3 different methods: Non-aqueous granulation, aqueous granulation, and direct compression. The prepared tablets were then tested for various evaluation parameters, including average weight, hardness, tapped density, Carr’s index, friability, and dissolution. The specifications were determined to be satisfied by every parameter. When compared to other batches and commercially available products, the investigation on the dissolution profile showed that product A3 (made using the direct compression method) had a quicker dissolving rate. The range of the assay values was between 90% and 110%. The main challenge in treating helminthes illness is the development of resistance in helminths to traditional anthelmintics. To clarify the prospective formulation, the anthelmintic activity of produced tablets was compared with that of the brand and generic allopathic dosage forms. For the in vitro comparative investigations on the anthelmintic activity against Indian worms (Pheretima posthuma), albendazole tablets were used in this work. For the activity, several concentrations of these formulations (10 mg/ml, 20 mg/ml, 30 mg/ml, 40 mg/ml) were utilised, with 0.5% of NaCl serving as the reference standard. To address the paralysis and death of earthworms, the results were expressed in terms of time in minutes.
