Damage Caused by Alcohol Use Disorder in a Series of Patients Presenting Bickerstaff Brainstem Encephalopathy
Author(s): Lourdes de Fatima Ibanez Valdes and Foyaca-Sibat Humberto*
Abstract
Background: Alcohol Use Disorders (AUDs) are a significant public health problem almost worldwide. Anatomical brain damage and an extension of dysfunctional neuronal network are some of the most adverse effects of AUDs. In patients presenting Bickerstaff Brainstem Encephalitis (BBE) the prognosis may be poor because caused by Brain-derived Neurotrophic Factor (BDNF).
Method: We searched the medical literature comprehensively, looking for published Medical Subject Heading (MeSH) terms like “Alcohol Use Disorder (AUD)”; OR “Bickerstaff Brainstem Encephalitis, (BBE)”.
Results: All selected manuscripts were peer-reviewed, and we did not find mpublications related to AUD/BBE.
Case series: We reported 4 cases presenting BBE with past social history of AUD.
Comments and concluding remarks: Adolescent presenting a comorbidity of AUD/BBE may have a poor prognosis due to replace the cellular tissue affected by BBE by neurogenesis because of decrease BDNF/AUD.
