Gastro Retentive Microspheres-Drugs for Parkinsons disease
Author(s): R.Prasanthi, B.Haarika and S.Selvamuthukumar
Abstract
Microspheres are small micron size particles ranging from 1 micron to 1000 microns and are free-flowing particles. These are prepared to acquire prolonged and controlled drug delivery to enhance the bioavailability, stability, and target-specific sites. These are made up of natural or synthetic polymers and these are of various types. In this review majorly three types of microspheres are discussed namely mucoadhesive or buccoadhesive microspheres, magnetic microspheres, and floating microspheres. General methods of preparation techniques like single emulsion, double emulsion, polymerization, solvent extraction, phase separation or coacervation, spray dryings or pray concealing, orifice ionic gelation method. Microspheres evaluation methods include flow properties, Swelling index, isoelectric point, in vitro dissolution test, ATR FTIR. Advantages, disadvantages, and their applications are discussed in detail. A note on Parkinsonism is added to the review. The scope to develop microspheres of MAO-B inhibitors and other agents in the treatment of Parkinson’s disease is discussed.