Synthesis, Pharmacological Evaluation of Novel Cinnamamide Derivatives Containing Substituted 2-aminothiophenes
Author(s): Satya Sree Bandaru
Abstract
The novel cinnamamide derivatives (C1-C12) were synthesized by treating substituted 2-aminothiophenes (A1-A12) with cinnamoyl chloride (B) in the presence of mixture of pyridine and acetone at 0°C. The structures of the novel amide derivatives confirmed based on functional groups, number of protons, number of carbons and molecular weight from FT-IR, 1H-NMR, 13C-NMR and mass spectra respectively. Further, the synthesized compounds evaluated for in-vitro antioxidant activity by DPPH and Hydroxyl radical scavenging methods and in-vitro anti-inflammatory activity by Protein denaturation and HRBC membrane stabilization methods. The results revealed that all the synthesized compounds showed good in-vitro antioxidant and in-vitro anti-inflammatory activities with reference to the standard drugs, Ascorbic acid and Ibuprofen respectively. Among all, C8 and C9 compounds showed good in-vitro anti-inflammatory activity.