The Potency of Asiatic Acid in Reducing Fibrosis after Strabismus Surgery via Type-2 Immunity Pathway: Review Article
Author(s): Harris Kristanto Gunawan, Evelyn Komaratih* and Rozalina Loebis
Abstract
Strabismus affects functionally, such as reducing binocular vision and causing diplopia, and also affects psychologically. Surgery is required for most strabismus cases, but excessive fibrosis can cause recurrent strabismus. Type 2 immunity is involved in the wound healing, and excessive inflammation from type 2 immunity can lead to excessive fibrosis. An extract from Centella asiatica, asiatic acid, has been studied that it can reduce inflammation and fibrosis in several organs. Asiatic acid can reduce inflammation caused by type 2 immunity by reducing IL-4. Asiatic acid has the potential to reduce fibrosis after strabismus surgery.
