Andrographolide Phytosomal Formulation for Enhanced Cognitive Resilience in Alzheimer?s Disease Model
Author(s): Kottapalli Vinay Kumar* and Kavitha N. Chilaka
Abstract
Alzheimer’s Disease (AD) is one of the common forms of dementia seen in elderly people. The present study was aimed at developing Andrographolide Phytosomes (AGP) and comparing it with the Andrographolide (AG) on scopolamine-induced Alzheimer’s disease by assessing cognitive function and biochemical markers. The Phytosomes confirmed characterization process FITR, DSC, Zeta potential, % Entrapment Efficiency and Scanning Electron Microscopy. AGP treatment significantly decreased the escape latency (p<0.01**) and improved conditioned avoidance response (p<0.001***) compared to AG. Pre-treatment with AGP significantly decreased acetylcholine esterase levels (p<0.01**) and increased hippocampal catalase (p<0.01**), superoxide dismutase (p<0.001***) and reduced glutathione levels (p<0.001***) which aligns with the results observed in the standard group when compared AG group indicating a preventive strategy against the progression of AD. This approach of AGP provides the potential therapeutic application in human neurodegenerative disease in future.
