Formulation and Optimization of Transferosomal Gel of Fusdic acid using Central Composite Design
Author(s): Sushma Chandrapalka* and Annammadevi G. S
Abstract
Introduction: Impetigo can be treated by using Fusicidic Acid (FA), in the present study transferosomes of FA were prepared and incorporated into gel and studied for drug release, extent of permeability into the skin.
Methods: In the process of preparation of transferosomes various lipids, edge activators with various conditions were tested and found that it had good solubility in Dimyristolyphosphatidylcholine and Tween 80. Rotary thin film hydration method was selected as a method of choice for preparation of Transferosomes. Various ranges of lipid: surfactant, stirring speed, %entrapment efficiency, %drug content, zeta potential, drug release etc parameters were studied for prepared transferosomes.
Results: Central composite design was used for optimizing the best formulation. Extrudability, viscosity, spreadability tests were performed for the prepared gels. CLSM studies were performed to identify the extent of drug permeability in to the skin layers.
Conclusion: From the above methods used and the results obtained, it was found that the Fusicidic acid gel prepared by using FF7 formulation was concluded as the best.
