Ajay Kumar

Department of Biotechnology, Rama University, Mandhana, Kanpur, Uttar Pradesh, India

Publications

• Research   
  In Silico based Identification of Novel Phytomolecules from Piper Longum for Drug Discovery against Cox-2
  Author(s): Indrajeet Singh, Hara Prasad Mishra, Pravesh Kumar and Ajay Kumar*
  
  Background: Acquired drug resistance is one of the key clinical problems and the main downsides of chemotherapy regimens for colorectal cancer. Using blend regimens, which mix conventional chemotherapeutic medications through plant-derived natural compounds derived from food or vegetation, is one of the most popular and efficient ways to overcome drug resistance and re-sensitize chemotherapy-resistant cells. Colorectal cancer is amongst the most common cancers. Despite improvements in its therapies, a fuller understanding of the molecular processes and genetic contribution to colorectal cancer will play a crucial role in the development of innovative and targeted treatments with improved safety profiles. In this review, the association between piperlongumine and Cyclooxygenases- 2 colorectal carcinogenesis, as well as potential mechanisms of action, are investigated. .. Read More»
  DOI: 10.4303/JDAR/236223

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