C.K. Dhanapal

Department of Pharmacy, Annamalai University, India

Publications

• Research Article   
  PREPARATION, EVALUATION AND STATISTICAL OPTIMIZATION OF PRASUGREL NANOSUSPENSION
  Author(s): P. Bhaskar Reddy, C.K. Dhanapal and Shaik Harun Rasheed*
  
  Background: To enhance the solubility of Prasugrel it was made in the form of Nanosuspension. Objectives: The study focused on the preparation of Nanosuspension which could improve the bioavailability. Methods: Various stabilizers were taken and verified in order to understand the solubility in suitable stabilizer. It was found that it had high solubility in Trilaurin and Evaporative Precipitation method was selected as a suitable choice. Results: The nanosuspensions prepared were statistically optimized using 3 level factorial design and from the overlay plot, it was further confirmed about optimized results obtained. Conclusion: The preparation of Prasugrel Nanosuspension resulted in improving the solubility, bioavailability when compared to the pure.. Read More»
  DOI: 10.4303/JDAR/236254

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