Dimas Arya Umara
Department of Cardiology and Vascular Medicine, Universitas Syiah Kuala, IndonesiaPublications
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Research Article
The Effect of Ascorbic Acid and Calcitriol on the Expression of Vascular Cell Adhesion Molecule-1 (V-Cam 1) in Aortic Early Atherosclerosis: An in vivo Study in a Mouse Model of Atherosclerosis
Author(s): Dimas Arya Umara, Teuku Heriansyah*, Sri Wahyuni, Haris Munirwan and Mudatsir
Background: VCAM-1 expression increases under conditions of high bioactive lipids such as dyslipidemia through the activity of oxidised LDL and triggers the early process of atherosclerosis. Ascorbic acid and Vitamin D are thought to have beneficial roles in aspects of suppressing inflammation, preventing oxidative stress and lowering lipid profiles in subjects at risk of cardiovascular disease. Method: This research is pure experimental research. The research design used was a posttest design with a control group (post-test only control group design). The research will be conducted at the Animal Experimental Unit and Anatomy Laboratory, Faculty of Veterinary Medicine, Syiah Kuala University. The samples of this study were 24 male Rattus novergicus strain Wistar white rats obtained from the Bogor Agricultural University (IPB) which were divi.. Read More»
DOI: 10.4303/JDAR/236247