Fang Huang
Department of Preventive Healthcare, Datuan Community Health Service Center, ChinaPublications
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Research Article
Genetically Predicted Omega-3 Fatty Acids Mediate the Association between SM23-33 Abundance in Stool and Childhood Obesity: A Mendelian Randomization Study.
Author(s): Min Zhang, Jinke Li, Fang Huang and Wenjuan Yan*
Background: Childhood obesity may be linked to gut microbiota and omega-3 fatty acids, but the precise relationships remain unclear. Objective: This study aimed to investigate the relationships between omega-3 fatty acids, the abundance of SM23-33 in stool, and childhood obesity. Methods: We performed Linkage Disequilibrium Score Regression (LDSC) to assess the genetic correlations among the abundance of SM23-33 in stool, omega-3 fatty acids, and childhood obesity. Additionally, bidirectional Mendelian Randomization (MR) analyses were conducted to explore the causal connections between SM23-33 abundance in stool and childhood obesity. A two-step MR analysis was used to determine whether omega-3 fatty acids, specifically Docosahexaenoic Acid (DHA), mediated these relationships. All statistical analyses were c.. Read More»