Novita
Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Syiah Kuala, Aceh, IndonesiaPublications
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Research Article
The Effect of Clitorea Ternatea Flower Extract Towards Interleukin 1-Beta, Nitric Oxide And Aorta Intima-Media Thickness In The Early Stage Of Atherosclerosis: In Vivo Study with Atherosclerosis Rats Model
Author(s): Onna Januaresty, Teuku Heriansyah*, Henni vanda, Fauzul Husna, Novita and Maha Fitra
Cardiovascular disease is caused by many things, especially atherosclerotic plaque. The process involves cytokines as a complex inflammatory response in the formation of atherosclerotic plaques. Interleukin 1-β (IL-1β) is a potent pro-inflammatory cytokine. It is also affected by oxidative stress. Clitorea ternatea was a plant in Indonesia that could be used as anti-inflammatory. The purpose of this study was to determine potential ability of Clitorea ternatea flower extract to reduce pro-inflammatory cytokine (IL-1β) expression, to increase antioxidant activity (Nitric Oxide), and to decrease tunica intima-media thickness in aortic histopathology in vivo related with early stage of atherosclerosis. This study was an experimental study and only posttest with control group design, using male white Rattus norvegicus W.. Read More»
DOI: 10.4303/JDAR/236211