Raja Sundararajan

Department of Pharmacy, GITAM Institute of Pharmacy, GITAM (Deemed to be University), India

Publications

• Research   
  Drug Elevating Efficiency: Validated RP-HPLC Method for Concurrent Detection of Cabotegravir and Rilpivirine in Medicine
  Author(s): Kiran Kumar Ganta and Raja Sundararajan*
  
  Background: Type I HIV can be treated by the combination of these drugs. A novel, precise, and accurate RP-HPLC technique was developed and validated for concurrent assessment of cabotegravir and rilpivirine in pure and medicinal dose form. Materials and methods: The analyte separation was achieved by Waters 2695 HPLC system that comprised of quaternary pumps and photodiode array detector. Mobile phase was in the ratio of (70:30 v/v) acetonitrile and 0.1N potassium di hydrogen phosphate. Flow rate of 1 ml/min was employed. The detector wavelength was at 257 nm. The run time was 5 min. Results: The regression equation for cabotegravir was found to be y=7596.9x+1542.1 and for rilpivirine it was y=7517.8x+5409. LOD values for cabotegravir and rilpivirine were observed to be 0.25 μg/ml and 1.79 μg/ml respectively.. Read More»
  DOI: 10.4303/JDAR/236406

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