Sri Raharjo
Department of Anesthesiology and Reanimation, Gadjah Mada University, IndonesiaPublications
-
Research Article
Acth4-10pro8-Gly9-Pro10 Administration Attenuate Ketamine-Induced Neurotoxicity in Post Natal Day-7 (Pnd-7) Rats: Effect on Caspase-3, Bcl-2, and BDNF Activity
Author(s): Raka Jati Prasetya*, Gontar A. Siregar, Nazaruddin Umar, Yetty Machrina, Sri Raharjo, Delfitri Munir, Dadik Wahyu Wijaya and Juliandi Harahap
Introduction: Ketamine is widely used as an anesthetic agent for children because of its safety and high efficacy in maintaining analgesia, spontaneous breathing, and hemodynamic stability. Nevertheless, recent studies showed ketamine exposure might compromise brain synaptogenesis, particularly in the growth spurt period of young animals. Here we investigate the neuroprotective effects of administration of ACTH4-10Pro8-Gly9-Pro10 can decrease neurotoxicity againts ketamine in PND-7 Sprague Dawley rats by investigating caspase-3, Bcl-2, and BDNF expression in the cortex and hipocampal tissue Methods: Subjects were PND-7 Sprague Dawley rats (n=33) and separated into three groups: K1–intranasal placebo and subcutaneous placebo treatment, K2–intranasal placebo and subcutaneous ketamine treatment, and K3–intranasal ACTH4-10Pro8-.. Read More»