Srinivasu Matta

Department of Pharmacology, Sri Vasavi Institute of Pharmaceutical Sciences, India

Publications

• Research Article   
  Pharmacodynamics and Pharmacokinetics Drug Interactions between ?-Mangostin and Gliclazide: A Pre-Clinical Study
  Author(s): Srinivasu Matta and Eswar Kumar Kilari*
  
  A study was conducted to investigate the impact of α-Mangostin on the pharmacodynamics and pharmacokinetics of gliclazide, a widely used drug for type II diabetes. The study was performed on normal rats, diabetic rats, and normal rabbits, with the administration of selected doses of gliclazide, α-Mangostin, and their combination. Appropriate washout periods were included between treatments. Blood samples were collected from rats and rabbits at regular intervals through retro-orbital and marginal ear vein punctures, respectively. All blood samples were analyzed for glucose using GOD/POD method, for serum insulin using ELISA method, and for gliclazide using HPLC. The results showed that gliclazide produced significant hypoglycemic and antihyperglycemic responses in normal/ diabetic rats and rabbits. The administration of a selected dose of &a.. Read More»
  DOI: 10.4303/JDAR/236239

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